2 4-Dinitrophenol / DNP /CAS: 51-28-5

Model NO.: steroids Assay: 99% MW: 184.11 Specification: 99% CAS: 51-28-5 Mf: C6h4n2o5 Trademark: JXK Origin: Zhuhai Product Description
2, 4-Dinitrophenol
Alias: DNP
CAS No: 51-28-5
MF: C6H4N2O5
MW: 184.11
Purity: 98%
Package: 1kg/foil bag
Appearance: Buff monoclinic crystal. Soluble in hot water, ethanol, acetone, benzene, chloroform and pyridine insoluble in cold water. Can with water vapor volatilization, heated sublimation.


Applications:
2, 4-Dinitrophenol (2, 4-DNP, or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. [1] It is a precursor to Other chemicals and is biochemically active, inhibiting energy (ATP) production in cells with mitochondria and was once used as a diet aid. It is produced by hydrolysis of 2, 4-dinitrochlorobenzene.

DNP was used extensively in diet pills from 1933 to 1938 after Cutting and Tainter at Stanford University made their first report on the drug's ability to greatly increase metabolic rate. After only its first year on the market Tainter estimated that probably at least 100, 000 persons had been treated with DNP in the United States, in addition to many others abroad. DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat. The inefficiency is proportional to the dose of DNP that is taken. As the dose increases and energy production is made more inefficient, metabolic rate increases (and more fat is burned) in order to compensate for the inefficiency and meet energy demands. DNP is probably the best known agent for uncoupling oxidative phosphorylation. The production or "phosphorylation" of ATP by ATP synthase gets disconnected or "uncoupled" from oxidation.

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